Mechanistic Aspects of Microbe-Mediated Nanoparticle Synthesis

Mechanistic insights into LDL nanoparticle-mediated siRNA delivery.

Although small interfering RNA (siRNA) can silence the expression of disease-related genes, delivery of these highly charged molecules is challenging. Delivery approaches for siRNAs are actively being pursued, and improved strategies are required for nontoxic and efficient delivery for gene knockdown. Low density lipoprotein (LDL) is a natural and endogenous nanoparticle that has a rich history...

Nanoparticle Synthesis and Characterization : a Mechanistic Study of Nanoparticle Morphological Evolution

Metal-Mediated Addition of N-Nucleophiles to Isocyanides: Mechanistic Aspects.

Despite the long history of the investigation of nucleophilic addition to metal-bound isocyanides, some important aspects of the reaction mechanism remain unclear even for the simplest systems. In this work, the addition of the sp³-N, sp²-N, and mixed sp²/sp³-N nucleophiles (i.e., HNMe₂, HN=CPh₂, and H₂N-N=CPh₂, respectively) to isocyanides C≡NR coordinated to the platinum(II) centers in the co...

Nickel-catalyzed triarylamine synthesis: synthetic and mechanistic aspects.

An improved protocol was described for the amination of chloroarenes with diarylamines under NiCl2(PCy3)2 catalysis in the presence of a Grignard reagent as base. This method fully suits bromo-/iodoarene substrates as well, and even is expanded to certain aryl tosylates. A preliminary investigation into the mechanism suggests that this amination reaction might proceed through Ni(I) and Ni(III) ...

Heterogeneous Copper Nanoparticle on Charcoal (Cu/C) Mediated Efficient Synthesis of 1-Substituted 1H-Tetrazoles under Solvent Free Condition

1-substituted 1H-tetrazoles were efficiently synthesized under solvent-free conditions from the reaction of primary amines, triethylorthoformate, and sodium azide in the presence of Cu/C as a heterogeneous catalyst. Various amines including aromatic and heteroaromatic amines were used to afford the corresponding products in good to excellent yields. The characterization of corresponding product...